Elucidating the mechanism of cellular

With these goals in mind, scientists around the world have performed thousands of large-scale genetic studies over the last decade.

Barts and the London School of Medicine and Dentistry, Greater London, E1 2AD, United Kingdom2.In the landmark TCGA study, the authors sequenced 20,661 protein-coding genes in 22 primary and secondary GBM tumor samples and used high-density oligonucleotide arrays to look for amplifications and deletions.They found that five of the samples (22%) had a heterozygous missense mutation in the IDH1 gene, a single base substitution of guanine for adenine, leading to arginine substituting for histidine at codon site 132 (R132H) in the mutant IDH1 protein.Keywords: IDH1 protein, glioma, DNA methylation, HIF1A protein, molecular targeted therapy, review Glioma is a broad term that includes primary malignant brain tumors of many types.Great effort has been expended to determine the genetic basis of these tumors, with the expectation that this knowledge will pave the way for the development of highly targeted therapies that will improve their generally poor prognosis. Astrocytoma is the most common, accounting for 70% of all cases, while oligodendroglioma comprises 9%, and ependymoma 6% [1].Conflicting findings from various studies are discussed, in order to highlight areas warranting further research.


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